Top Nail Fungus Treatments Rated for 2022

Learn which treatments can cure nail fungus safely at little to no cost, which prescription medication can cause liver damage and simple at home remedies some people swear by.


Which Treatments Work For Nail Fungus Infections?

Fungal infection of the nails (nail fungus) medically known as Onychomycosis, is a very common condition especially in the toenails. For most people, nail fungus is not a health risk, but more of a cosmetic problem. However If you are diabetic, have poor circulation and/or a weakened immune system, nail fungus can become a very serious problem.

It is imperative to treat nail fungus quickly once an infection starts.

Most nail infections are caused by dermatophytes, called that because they only infect the skin (or dermis) and skin structures like nails. Trichophyton rubrum and Trichophyton mentagrophytes cause most of the infection, with T. rubrum responsible for as many as 90% of onychomycosis cases. Candida (yeast) as well as certain molds can also infect nails.


Diagram of Toenail Fungus

How to Treat Nail Fungus

There are a number of ways to deal with onychomycosis. They almost always include cutting away as much of the affected nails first. These include:

The top 3 natural nail fungus treatments ranked as per effectiveness: (Click each link to read full reviews and product details)No.1 Rated: Zetaclear – Learn More Here

No.2 Rated: Funginix – Learn More Here

No.3 Rated: Purnail – Learn More Here

With the right treatment, you should be able to get rid of a nail infection caused by fungus, even if you’ve had it for years or it’s very bad. But you may have to be patient. It could take months to clear up.

Key points about treating fungal nail infections

  • To get rid of a fungal nail infection, you will probably have to take a treatment, sometimes for up to six months.
  • Fingernail infections tend to clear up quicker than toenail infections. You may need to take medication for only six weeks for a fingernail infection.
  • Some Prespcription Medication can sometimes damage your liver (though this is rare) and you may have a test to check if your liver is healthy before starting a nail fungus treatment.
  • Normally doctors recommend pills for this condition, but there are also treatments you can put on an infected nail. If the problem is mild, you might be given a nail varnish or use tea tree oil that kills the fungal infection.
  • If your infection is severe or keeps coming back, your doctor might recommend removing part or all of your nail. But this treatment is rarely used.
  • If your nail infection doesn’t bother you, you may wish to leave it alone.


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Nail Fungus Treatments – What Everybody Ought to Know

By: Susan Miller MS BSN RN

Nail fungus, otherwise known as Onychomycosis, has been recognized as being a very difficult type of fungal infection to treat. It is a cosmetic condition that most often affects the toenails. Risk factors for nail fungus include increased age, male gender, diabetes, nail trauma, hyperhydrosis, peripheral vascular disease, athlete’s foot, immunodeficiency, poor hygiene, and chronic exposure of the nails to water. There are many species of fungus that can infect the nail. Often in nail infections several types of fungus will be present at the same time. All nail fungus infections result in thickened, discolored, and distorted nails.


In the past, treatment options were limited and often not very effective. Now there are several treatment options available to cure nail fungus. It is important to see your health care provider to ensure that it is truly a fungal infection you are dealing with before any treatment starts. There are other disorders (such as: Psoriasis, Lichen planus, contact dermatitis, and certain bacterial infections) that can cause similar looking nail problems. Your doctor can verify if it is indeed a fungal infection by examining nail scrapings and clippings under a microscope and submitting these samples to a lab to be cultured.

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Can CBD Oil ( HEMP ) cure Toenail Fungus? The results may shock you.

Fungal infections in general, and particularly the infection of a nail plate pose a considerable treatment challenge. The reasons are many; the nail plate structure, the fact it lacks reparation mechanisms (most of it is out of the reach of the immune system), the speed of its growth (slow), and the biological characteristics of the fungi.

cbd oil

The therapeutic properties of CBD oil have been intensively studied in the past few decades with somewhat encouraging results. Research shows it has neuroprotective properties [1], changes psychological response to food (obesity treatment) [2], can be used as a painkiller in certain conditions [3], and there are encouraging results in cancer treatment as well [4]. The health benefits of CBD oil does not end here- at any given moment, dozens of preclinical and clinical research studies are conducted across the world while the body of evidence updates daily. Multiple sclerosis, HIV, opioid addiction, various psychiatric conditions, and cancer are only some of the areas CBD oil research focuses on.

But, can it treat toenail fungus? This article is all about CBD oil in the treatment of toenail fungus. Theoretical and practical concepts, research studies and experiences of people who used it for the treatment of toenail fungus.

Cannabinoids and terpenoids- a short guide through their (documented) effects

Cannabis or hemp is a plant CBD manufacturers use to extract the cannabinoids from it- substances with proven therapeutical effects for human health. The cannabinoid oil consists of two main fractions- CBD (cannabidiol) and THC (tetrahydrocannabinol). Other than those, different hemp strains contain more or less of other fractions, such as Cannabigerol (CBG), Cannabinol (CBN) and CBC (Cannabichromene). Each of those slightly differs from each other and have different health effects. Besides cannabinoids, another group of molecules also plays a significant role in hemp therapeutic properties. Those are terpenoids- aromatic compounds found in many plants, chemically quite diverse whose effects to humans reach far beyond the nose.

Using sophisticated technology, manufacturers separate the CBD from THC. The separation is needed to avoid well-known psychoactive effects and to eliminate the risk of addiction while preserving all therapeutic properties of the cannabis. The effects of CBD and THC are opposed to each other in some cases- while the CBD is used to put the appetite under control, THC stimulates it. Depending on the extraction technology used, final product- CBD oil contains more or less other fractions and no THC (the whole point of the legislation is to prevent THC spreading around as an OTC remedy).

Except the above mentioned two fractions, CBN (Cannabinol) and CBC (Cannabichromene), make significant fractions of cannabinoids. CBN is a degradation product of THC of no particular importance for health. On the other hand, CBC is a lot more interesting as it shows stronger antibacterial and antifungal effects than CBD. However, compared to conventional treatments, it’s antifungal effects are described as “mild”[5].

    Cannabigerol (CBG), a biochemical precursor of cannabinoids mentioned above is another member of a cannabinoids family. It shows the strongest antifungal and antimicrobial effects compared to CBN and CBC [6].

    Cannabis contains more than 100 different terpenoids as well. The distinctive smell of marijuana comes from these molecules- terpenoids are what the police dogs are trained to smell when searching for weed. Hemp strains used for the production of CBD oil are not as aromatic as marijuana; therefore they contain a lot less of terpenoids. One of these compounds is particularly known for its antifungal properties, and it’s called Caryophyllene oxide. It’s the only compound of hemp plant with antifungal properties stronger than conventional antifungal drugs. Back in 1999, a group of researchers used a sheep hoof plates to simulate human nails in order to research the antifungal properties of Caryophyllene oxide. The effects were comparable to those of the ciclopiroxalamine and sulconazole- the eradication was achieved after 15 days. This is the most important study about antifungal properties of a hemp compound after topical application [7].      

Online reports

    Despite the limited data about the efficacy of CBD oil topical application in toenail fungal infections and research that suggests it’s less effective than conventional treatments, there are anecdotal reports of its miraculous effects unpaired to any other “classical” approach. However, all those reports from different forums have pretty much the same format- there’s that one guy who had a nasty infection for years, an army of doctors around him was wondering how they could help, suggesting treatments that completely failed and then, almost accidentally, he discovered the miraculous effects of CBD oil. The problem disappears virtually overnight never to return back.

    Does it really works or it’s just a “gray hat” marketing campaign of affiliate associates? It depends whom you ask- people want to believe it works and that’s perfectly ok. Cosmetic defects of any kind are not something people handle very well, and toenail fungus is, for sure, one of those things that hurt the self-esteem more than a toothache will ever hurt.

To try it or not to try it?

So, is a CBD oil pure extract, or it contains other fractions? The whole process of CBD production turned into a lucrative business in the last 10 years. Some estimates say that CBD market net worth will reach $2.1 billion by 2020.  Legislation has not yet reached the level of “minor sub-fractions.” The chances are, in the next few years, “highly specialized” blends will be introduced to the market (it’s already happening in cancer treatment), and until that happens using commercially available CBD oil seems to be the only option.

Having in mind the treatment is safe and, practically without any side effects, it’s worth trying. At this moment, it’s safe to experiment with it- the chances are it won’t do much, but… There’s always a glimpse of hope it might work in your particular case.

Despite not so optimistic expectations at this moment, the chances are we will witness a novel and very effective CBD oil treatment of toenail fungus in the coming years. Until that happens, keep an eye on research studies!


[1] Dexanabinol (HU-211) effect on experimental autoimmune encephalomyelitis: implications for the treatment of acute relapses of multiple sclerosis. Achiron A, Miron S, Lavie V, Margalit R, Biegon A J Neuroimmunol. 2000 Jan 3; 102(1):26-31.

[2] Efficacy of rimonabant and other cannabinoid CB1 receptor antagonists in reducing food intake and body weight: preclinical and clinical data. Carai MA, Colombo G, Maccioni P, Gessa GL CNS Drug Rev. 2006 Summer; 12(2):91-9.

[3] Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial. Berman JS, Symonds C, Birch R Pain. 2004 Dec; 112(3):299-306.

[4] Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review). Bifulco M, Laezza C, Gazzerro P, Pentimalli F Oncol Rep. 2007 Apr; 17(4):813-6.

[5] John M. McPartland DO, MS & Ethan B. Russo MD (2001) Cannabis and Cannabis Extracts, Journal of Cannabis Therapeutics, 1:3-4, 103-132.

[6]  ElSohly, H.N., C.E. Turner, A.M. Clark, and M.A. ElSohly. 1982. Synthesis and antimicrobial activities of certain cannabichromene and cannabigerol related compounds. J Pharmaceut Sci 71:1319-23

[7] Russo, E. B. (2011). Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology, 163(7), 1344–1364.

My Personal Journey in Curing Nail Fungus for Good – A Weekly Treatment Diary

This is a guest post series from a follower of the blog. The goal is to chronicle the various ways one person can treat and get rid of nail fungus for good. We hope you enjoy!

Week 1 – Hi my name is John and if you are like me one day you looked down at your feet and thought wow my toenails look pretty gross. Could be at a pool party, walking on the beach or just wearing your flip flops out in public. For me I love training in martial arts. In the martial arts gym you are always barefooted. No shoes allowed! It was there one day that it hit me, amongst all these 20 somethings with clear nails my nails looked yellow and crusty. It was really embarrassing and I vowed to clear them up once and for all.

Nail fungus never really appears out of the blue… its a gradual thing… get a crack in your nail… walk around the shower in the gym barefooted… wearing your shoes constantly without letting you toes breath and next thing you know your nail start getting little cracks and discolored. My story is that I took a break with martial arts training to have a family and to work on my career and so after 5 years decided to starting training again.  I never really cared what my feet looked like, however that changed when I got back into martial arts.

In the gym you are training in close quarters, whether you are grappling, wrestling or sparring so being clean and cleanliness in general is of a high concern. You don’t want to be that guy that has terrible body odor or super bad breath…

Now I’m no spring chicken but I’m not “old” either I’m in my late 30s but when I stepped onto the mat I noticed right away how gross and yellow my big toenail looked. Now I looked at my feet a millions times before that day stepping onto the mat, but never really noticed or cared. Yet here I was the “older” guy in the gym looking quite the part with my yellow nails and all.


From that day forward I always hid my toenail with black tape when I was in the gym. From time to time someone would ask me why I was wearing the tape and I would usually say “oh I jacked up my toes hitting the heavy bag” or “tweaked them while sparring”… at this point no one evens bothers anymore… as they must be thinking his toes are permanently screwed up!

If you take a look at the picture you can see why I usually wrap them up. They look gross!

So I have to do something… I can’t always wear tape around my toes and summer is coming up! So I’m going to detail here my experience in trying the various methods of curing my nail fungus on this blog. Following along with me and leave your comments below!

Week 2


So my strategy is just to go to local drug store and pick up a cheap bottle of anti-fungal solution from CVS. I’m using undecylenic acid. Also I’m filing my toenail down. It way too early for any real results but I think filing down the crusty parts is better than nothing at all.


Week 4

Not much has changed.  Just plugging away and applying the CVS treatment daily as well filing the yellow parts down.  I think the root base of the nail is not yellow but it seems that the nail as it grows out develops a yellow tinge as well as gets flaky and not healthy looking.

My plan is to finish the bottle out in another few weeks before switching up my treatment options.



The Science Behind Topical Toenail Fungus Treatments

In this article you will learn how topically applied treatments are used to treat nail fungus:


1. The anatomy of the human nail
2. The organism behind nail fungus
3. How topical treatments work

1. The anatomy of the human nail


The skin is the largest organ in the body and its most important function is to provide a selectively permeable barrier to the outside environment. The outermost layer of skin is called the stratum corneum (SC), Latin for horned layer, which is a dynamic structure that functions to protect deep layers of the skin from infection and injury [1]. This layer is comprised of dense skin cells (15 layers deep) called corneocytes [2] that originate deep within the skin and migrate to the surface of the skin as they mature. Complete replacement of these cells in the epidermis takes approximately 1-2 weeks, as it takes about 24 hours to form a single layer of the SC. One of the most important structures of the SC is the nail, which is a flat, hardened covering at the tips of the fingers or toes that has evolved to function as a protectant for the tips of our digits. The nail covers and protects a part of the finger called the matrix (see below), which is a layer of skin under the nail from which all of the cells that become the nail arise [3].

Nail Structure

The nail itself is comprised of three main layers. From the outer structure in, they are the nail plate, the nail bed, and the nail matrix. The nail plate, also called the dorsal outer layer, is dense and hard, consisting of keratin [4]. The nail plate is a thin (0.25 -0.6mm for fingernails and up to 1.3mm for toenails), hard, yet slightly elastic, translucent, convex structure that is made up of approximately 25 layers of dead keratinized and flattened cells. These cells are tightly bound to one another via numerous intercellular links, membrane-coating granules and desmosomes, which are cell structures specialized for cell-to-cell adhesion [4].

The nail bed is the skin beneath the nail plate [5]. Like all skin, the nail bed is made of two types of tissues: deep dermis, (the living tissue fixed to the bone which includes capillaries and glands), and the superficial epidermis (the layer just beneath the nail plate, which moves forward with the plate). The epidermis is attached to the dermis by tiny longitudinal “grooves” known as matrix crests.

The nail matrix (sometimes called the matrix unguis, keratogenous membrane, or onychostroma) is the tissue that the nail protects [6]. This part of the nail bed rests beneath the nail and contains nerves, lymph and blood vessels. The matrix is responsible for producing cells that become the nail plate. The width and thickness of the nail plate is determined by the size, length, and thickness of the matrix, while the shape of the fingertip itself shows if the nail plate is flat, arched or hooked [6]. The nail matrix continuously produces nail. The matrix at the base of fingernails consists of the most rapidly dividing skin cells in the body, which grow four times faster than toenails at a rate of about 3mm a month. This tissue consists of rapidly proliferating skin cells that soon fill with the protein keratin. This is the protein that gives strength to the nail [7].

The nail-plate (corpus unguis) is the actual nail that we usually refer to as the “fingernail” or “toenail.” This part of the nail is made of a clear protein called keratin. Several layers of dead, flattened cells make the nail strong and able to protect the end of the finger, yet partially flexible. The nail-plate is comprised of dorsal, intermediate, and ventral layers. The dorsal outer layer is dense and hard, consisting of keratin. However, despite its hardness, this layer of the nail is only a few cells thick (approximately 0.5mm) [8]. The dorsal and ventral layers of the nail plate have the highest concentration of lipids in the nail, and affect penetrability of treatments (see below) [9]. In intermediate layer of the nail plate contains highly compressed, flattened cells, in comparison with the other two layers, which contain softer, less compressed cells [10].

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Can Baking Soda Cure Nail Fungus?

Eww, nail fungus! Who wants to have brittle, discolored nails that keep you from reaching out to shake someone’s hand or from wearing open toed shoes? To make matters worse, if you go to your doctor, he will likely hand you a powerful anti-fungal medication that you need to take for months. Not only does that medication have side effects, it is often unreliable, expensive, and not covered by insurance.

The good news is that you can heal your nail fungus cheaply and naturally without much effort. Baking soda is one of the most common substances in your house, but it is scientifically proven to stop the spread of nail fungus. This will help keep it to one finger or toe, and it will stay localized to just one place on the nail. Tea tree oil is another topical medication that has anti-fungal properties to kill off the bugs in your nail. Used together, these all natural remedies provide a safe, effective way to manage a nail fungus problem.

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Amorolfine and Onychomycosis (Nail Fungus)

Fungal infection of the nails, called onychomycosis, is very common but difficult to treat. There is still no guaranteed way to cure the infection, no matter what treatment is chosen, but there are a number of ways to improve the appearance of the nails, lessen the infection, and perhaps cure it in some people. While there is a lot of agreement between medical professionals who treat this all over the world, the same medicines are not always available in different countries.

The two types of medical treatment are topical, medication applied directly to the affected nail or nails, or oral, taking medicine by mouth so it will get to the nail via the bloodstream. Oral medications usually have to be taken for 12 weeks, and achieve a “cure” from 60% to 75% of the time. However, these drugs have side effects including the potential for liver damage. Recurrence is common, from 10% to 50% of the time. Recurrence may be less likely if topical medicine is used on the nails; using both oral and topical medication may also improve the chance of eliminating the infection.

Oral medications are not able to actually kill all the fungus in infected nails, even if they can in the laboratory. The same thing can be said about topical medications. One idea is to combine the two to kill as many fungi as possible. For toenails, this must always be done along with cutting off as much infected nail as possible.

There are no FDA approved over-the-counter treatments available in the United States. There are creams made to treat athlete’s foot (a fungal infection of the skin) that can be used on toenails with varying success. These included Lamisil® (terbinafine), Nizoral® (ketoconazole), Mycelex® (clotrimazole), and Naftin® (naftifine), which are available without a prescription as well as with a prescription. The prescription medications are usually stronger. There are a couple of choices of topical medications FDA approved for fungal infection of the nails in the United States. These include ciclopirox lacquer (Penlac®) and tolnaftate 1% solution (called Formula 3).

A medicine used in many other parts of the world for the last 20 years is called amorolfine (trade name Loceryl®). It seems to be as safe and effective, if not more so, than the topical medications approved for use here. However, it is not FDA approved, and cannot be acquired in the United States or Canada. There are studies of its effectiveness and safety available because it is in use in Europe, the UK, and other places such as Australia. It can be ordered from other parts of the world.

Amorolfine is a different class of antifungal medication than the other topical drugs. It is active against essentially all the main classes of fungus that infect nails. Fungi called dermatophytes (meaning they like skin and skin structures like nails) are the most common causes of the infection. There are a few other fungi and mold that can cause onychomycosis and amorolfine can kill or stop these from growing in a laboratory setting. It works by damaging the membrane around the fungal cells. This kills dermatophytes like Trichophyton rubrum, the most common fungus involved. However, it does not always kill all the fungus in nails because it is very hard for it to reach every area of infection.

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How to Use Topical Nail Fungus Treatments

Sometimes just using a topical nail fungus treatment isn’t quite enough. Nail fungus is a difficult condition to treat – even if you do break down, go to the doctor, and get high-powered prescription medications – and you need to try multiple approaches to find something that will work. The problem is that the fungus gets down underneath the nail, and the nail’s primary job is to protect the soft tissue underneath from the outside world. Unfortunately, this means it protects the fungus from the healing powers of just about everything that you try to throw at it.


If you want to get rid of your nail fungus, you are going to have to stay dedicated to the task and try as many different remedies as you can. Don’t give up too soon on something, though. It can take months to see any improvement in nail fungus, even with doctor prescribed treatments. With home remedies, you have to use the treatments consistently and loyally, even when it seems like it won’t work. Of course, your best course of action is to prevent nail fungus from the start.

Tips for Using Topical Nail Fungus Treatments

If you have a topical nail treatment for your nail fungus, you are ahead of the game, but you can do a few things to make that treatment even more effective than merely rubbing it on your nail and leaving it alone. Topical nail treatments need to penetrate the hard, brittle nail that the fungus has created. Unfortunately, nail is not absorbent, so if you have thick nails, that topical solution is just sitting on top of the nail and not attacking the fungus. For starters, keep your nails clean and dry at all times. Fungus and bacteria in general love a warm, wet environment. If you have sweaty feet, use an anti-fungal foot powder to keep your feet dry.

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PurNail Nail Fungus Remedy Review

PurNail Nail Fungus Remedy is an all-natural alternative to the more aggressive products on the market for treating nail fungus. Rather than taking a powerful anti-fungal by mouth, you can use this topical treatment to help rid yourself of the fungus that is growing under the nail. It will take some time for this treatment to work. though. The product estimates that you will need about a three to four month supply, but if you do not want to take prescription medication or they are not effective for you, then scrubbing on a topical treatment might be the solution that takes care of your embarrassing nail fungus.


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Dr. Pauls Piggy Paste Review – Does this work to clear up Nail Fungus?

Nail fungus is a fungal infection of one or more of the nails on the fingers or toes. These infections typically begin as a yellow or white spot underneath the tip of the fingernail or toenail, and then progress deeper into the nail. They can cause the nail to discolor, thicken, and even crumble at the edges. Fungal nail infections are often difficult to treat and may recur following successful treatment.

Many over the counter (i.e., non-prescription) anti-fungal treatment options are available, however some are not very effective at treating true nail fungal infections. Oral prescription medications, such as Lamisil and Sporanox, can be  an effective means of treating fungal nail infections as well as tea tree oil, but treatments can take as long as four months to fully work. Other treatment options include a prescription antifungal nail polish called Penlac, however this make take up to one year to show improvement. In addition, some topical medications may be used along with a prescription medication.

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Nail Fungus Sufferers: What Works and What Doesn’t?

Are you tired of suffering from stubborn and ugly nail infections? Do you long for letting your once beautiful toes see the sunlight again? Do you wonder what it’s going to take to get rid of the fungus?

Over the years we’ve had the opportunity to collect testimonials from people who left comments on, who have used different types of nail fungus remedies. After analyzing them, we’ve created some useful suggestions for those who want to eliminate nail fungus.

Of course, nothing is ever 100% guaranteed, but if we can learn from others with similar problems, we have a better chance of crossing off one more problem we have from the list that seems to accumulate many problems as we age.


How Doctors Heal Patients

In fact, I was thinking about doctors and how they learn. I know that if you ask any doctor who he or she learned the most from, they will say their patients. In the practice of medicine, a doctor who pays the most attention to the results that their patients are receiving, and makes appropriate adjustments is often the most successful – both with people and against disease.

Recognizing this feedback loop was very valuable, we started collecting reports on remedies from our readers and have been able to create some basic guidelines for anyone with nail fungus problems who wants to use these treatments to get clear nails again.

Guidelines From Our Readers about Nail Fungus Remedies

Remedies for nail fungus are plentiful. Lamisil, a prescription and over-the-counter medication, is often recommended by medical doctors; both general practitioners and dermatologists. Home remedies such as tea tree oil, hydrogen peroxide, vinegar, or even Vick’s Vapor Rub could work. Even Star Trek technology has hit the nail fungus scene and doctors may use laser to zap the fungus into infinity. All of these remedies have good possibility of being successful.


Whatever remedy you use, remember that it’s not enough to focus on the remedy itself. You still have to clean the nail – and do it right. And you still have to thoroughly wash your feet daily.

The treatments must reach the nail bed. The fungal infection starts at the nail bed, not on the nail itself. Nail beds are composed of a thick keratin layer and your remedy must penetrate this to get those fungi predators that are lurking below the surface, knowing that they are well out of your reach. Develop a fungi killer mentality, as if you will be relentless about any of their lives!

General foot care is imperative: always trim and file down your nails. Also, don’t hide your feet, as difficult as it may be. Keep your nails and toes well-ventilated. And as much as you want to paint your toenails, don’t do it. Healing will need the area to be undisturbed.

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Treating Nail Fungus with a Weakened Immune System

People suffering from a compromised immune system are naturally more likely to develop an infection, whether it is viral, bacterial, or fungal in nature. The concern for this issue is that without a strong immune response the infection can spread and progress to life threatening proportions.


A normally functioning immune system is typically capable of fighting an infection and controlling it, perhaps with the aid of a medication. At some point during a person’s lifetime they may experience a suppression of the immune system for one reason or another, which then allows the dormant fungus to become active causing health complications.

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